Folic Acid supplementation appears to be well tolerated at the recommended doses. However, flushing, fatigue, rash, itching, allergic reactions, etc. have been reported. The risks of higher levels of Folic Acid supplementation are believed to be minimal. Folic Acid is considered nontoxic even at very high doses and is rapidly excreted in the urine. However, because the effects of high intakes are not well known but include complicating the diagnosis of vitamin B-12 deficiency, care should be taken to keep total folate consumption at less than 1 mg per day, except under the supervision of a physician.